(Full term: single domain antibody ). Antibodies with only one (instead of two) protein chain derived from only one of the two domains of the normal antibody structure. Exploits the finding that for some antibodies, half of the molecule binds to its target antigen almost as well as the whole molecule. The major advantage of dAbs over other antibodies is that they can be cloned and expressed into bacteria, so that large numbers of antibodies can be generated and screened in parallel.
- Browse Related Terms: abzyme, antibody class, antibody structure, complementarity-determining regions, DAB, Fab, FC, hypervariable region, IgA/Igd/IgG/IgE/IgM, immunoglobulin, immunosensor, in situ hybridization, kappa chain, lambda chain, V region