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Human Genome - A hybrid cell containing small fragments of irradiated human chromosomes. Maps of irradiation sites on chromosomes for the human, rat, mouse, and other genomes provide important markers, allowing the construction of very precise STS maps indispensable to studying multifactorial diseases. See also: sequence tagged site
Human Genome Project - Cite This Source - This Definition - Browse Related Terms: candidate gene, contig, Contig map, fluorescence in situ hybridization (FISH), Gene, Morbid map, positional cloning
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Human Genome - The process by which progeny derive a combination of genes different from that of either parent. In higher organisms, this can occur by crossing over. See also: crossing over, mutation
Human Genome Project - Cite This Source - This Definition - Browse Related Terms: Bioremediation, Chimera (pl. chimaera), Coisogenic or congenic, DNA bank, fibroblasts, Gyandromorph, Murine, proteome, Wild type, xenograft
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Human Genome - A DNA base sequence that controls gene expression.
Human Genome Project - Cite This Source - This Definition - Browse Related Terms: Base sequence, Base sequence analysis, Complementary sequence, DNA sequence, DNA sequencing, Full gene sequence, Genomic sequence, High-throughput sequencing, Sanger sequencing, sequence, Sequence assembly, Sequencing technology, Shotgun method, shotgun sequencing, Structural genomics
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Human Genome - A specific nucleotide sequence of DNA at which a particular restriction enzyme cuts the DNA. Some sites occur frequently in DNA (e.g., every several hundred base pairs); others much less frequently (rare-cutter; e.g., every 10,000 base pairs).
Human Genome Project - Cite This Source - This Definition - Browse Related Terms: Endonuclease, Long-Range Restriction Mapping, Macrorestriction map, Rare-cutter enzyme, Restriction enzyme, endonuclease, restriction enzymes, Restriction-fragment-length polymorphism (RFLP)
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Human Genome - Variation between individuals in DNA fragment sizes cut by specific restriction enzymes; polymorphic sequences that result in RFLPs are used as markers on both physical maps and genetic linkage maps. RFLPs usually are caused by mutation at a cutting site. See also: marker, polymorphism
Human Genome Project - Cite This Source - This Definition - Genetic variations at the site where a restriction enzyme cuts a piece of DNA. Such variations affect the size of the resulting fragments. These sequences can be used as markers on physical maps and linkage maps. RFLP is also pronounced "rif" lip. See also enzyme, polymorphism, linkage
National Human Genome Research Institute - Cite This Source - This Definition - Browse Related Terms: Endonuclease, Long-Range Restriction Mapping, Macrorestriction map, Rare-cutter enzyme, Restriction-enzyme cutting site, Restriction enzyme, endonuclease, restriction enzymes
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Human Genome - The presence of retroviral vectors, such as some viruses, which use their recombinant DNA to insert their genetic material into the chromosomes of the host's cells. The virus is then propogated by the host cell.
Human Genome Project - Cite This Source - This Definition - Browse Related Terms: bacterial artificial chromosome (BAC), bacteriophage, cloning vector, cosmid, gene transfer, P1-derived artificial chromosome (PAC), phage, plasmid, Transfection, Vector, Virus, yeast artificial chromosome (YAC)