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• An adaptive physiological state that occurs with regular drug use and results in a withdrawal syndrome when drug use is stopped; often occurs with tolerance. Physical dependence can happen with chronic—even appropriate—use of many medications, and by itself does not constitute addiction.

  National Institute on Drug Abuse - Cite This Source - This Definition
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  Cite Definition for Physical Dependence

  American Psychological Association (APA)

  Physical Dependence. (n.d.). NIH Prescription Drug Abuse Glossary. Retrieved February 9, 2023, from website: http://www.expertglossary.com/definition/physical-dependence.

  Chicago Manual of Style (CMS)

  Physical Dependence. www.drugabuse.gov. NIH Prescription Drug Abuse Glossary. National Institute on Drug Abuse. http://www.expertglossary.com/definition/physical-dependence (accessed: February 9, 2023).

  Modern Language Association (MLA)

  "Physical Dependence." NIH Prescription Drug Abuse Glossary. National Institute on Drug Abuse. 9 February. 2023 http://www.expertglossary.com/definition/physical-dependence.

• Browse Related Terms: addiction, central nervous system, Comorbidity, Dopamine, Norepinephrine, Physical Dependence, Stimulants, Tolerance, Withdrawal

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