knockout

Inactivation of specific genes. Knockouts are often created in laboratory organisms such as yeast or mice so that scientists can study the knockout organism as a model for a particular disease. See also gene, locus

Deactivation of specific genes; used in laboratory organisms to study gene function. See also: gene, locus, model organisms

A mutant individual, in which a single functional gene has been replaced by a non-functional form of the gene. Used to understand gene function via the comparison of the phenotypes of wild type and knockouts.